Best Methylation Support for 2025

By Customer Ratings

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Pure TheraPro Rx Methylation Support - Stabilized Health Care Supplement For An Improved B... Read Review

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Product Highlights

  • Made in the USA with FDA quality standards
  • Combined with Trimethylglycine and Vitamins B2/B6/B12
  • Works actively on heart health and neuro systems 

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Thorne Research - Riboflavin 5'-Phosphate - Bioactive Form of Vitamin B2 for Methylation S... Read Review

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Product Highlights

  • Active B2: The active form of vitamin B2 more readily used by the body*
  • B Vitamin Formation: Important for the formation of other B vitamins, including niacin and active B6
  • Methylation: Provides support for healthy methylation*
  • Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts). This product also contains no soy, dairy, yeast, shellfish, or fish.
  • Thorne's commitment to integrity and science-backed products has helped us earn the trust of thousands of health-care professionals, U.S. National Teams, the Mayo Clinic, and families around the world.
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Pure Encapsulations Ultra B-Complex with PQQ | Vitamin B Supplement to Support Nerves, Cel... Read Review

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Product Highlights

  • Mitochondrial Function: B-complex vitamins are essential to basal mitochondrial function as metabolic coenzymes and methyl donors, while PQQ provides novel B-vitamin like activity and alpha lipoic acid for advanced antioxidant support.*
  • Nerve Health: Thiamine and niacin support healthy neuron cell longevity, neuronal membrane function and impulse conduction. 5-MTHF, methylcobalamin, adenosylcobalamin, and vitamin B6 support neuronal health as methylation cofactors in myelin and neurotransmitter biosynthesis.*
  • Macrophage Support: One ingredient, luteolin, supports healthy macrophage activity and gene expression of the nervous system.*
  • Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
  • Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.
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MethylPro 15mg L-Methylfolate (90 Capsules) - Professional Strength Active Methyl Folate,... Read Review

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Product Highlights

  • The Leader In Faster, Active Folate - Approximately half the US population may have difficulty converting folate into its active form. MethylPro is the leading nutraceutical line featuring l-methylfolate, the most advanced form for better results.*
  • Professional Strength - Many methylfolate products contain mcg or 1mg amounts. MethylPro offers a range of potent therapeutic doses. This 15 mg dose is our strongest, for a difference you can feel.*
  • Brain & Mood Support - Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, energy, hormones and mood stability. This is the only form of folate to cross the blood-brain-barrier.*
  • Promotes Cardiovascular & Nerve Health - May help promote heart health & healthy peripheral nerve function by supporting already healthy homocysteine levels and nitric oxide production.*
  • No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. The only additional ingredient is the amino acid glycine. This product is free of soy, gluten, dairy, eggs, and nuts. Take only as directed under the supervision of a Physician.*
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Liposomal Liver Detox + 120 Acid-Resistant VCaps | Soy-Free Liposomal Format Containing Me... Read Review

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Product Highlights

  • SUPPORTS DETOXIFICATION & HEALTHY AGING this formula is an advanced supplement that supports the liver. It contains European Milk Thistle 30:1 Extract & Standardized 80% Silymarin, along with Artichoke Extract, Taurine, Alpha-lipoic Acid and Patented Acetylated Glutathione (Emothion) - all playing a significant role to clean and detoxify the liver.
  • MICRO ENCAPSULATED in a Soy-Free Liposomal Format: Phosphatidylcholine (or PC), is a natural phospholipid molecule and the major lipid, or fat, of cell membranes and blood proteins. It serves as the body’s main source of choline, an essential nutrient. Our Phosphatidylcholine Complex is derived from certified non-GMO Sunflower and is a powerful anti-inflammatory, supporting gastrointestinal health, cell repair, as well as normal liver & lung function
  • METHYLATION NUTRIENT COFACTORS: Selenium (SelenoExcell), Riboflavin (as riboflavin-5-phosphate), Molybdenum (as TRAACS Molybdenum Glycinate Chelate), MicroActive PQQ and Trimethylglycine (TMG)
  • SUPPORTS Detoxification, Methylation, Optimal Cell Function & Healthy Aging. May Help Support the Body’s Healthy Free-Radical Defenses and Liver Health
  • WHAT'S NOT THERE IS ALMOST AS IMPORTANT AS WHAT IS: We formulated our product with your needs in mind, that's why it is non-GMO, soy and gluten free, and unlike other brands does not contain the additive magnesium stearate which is thought to potentially inhibit absorption of key nutrients.Manufactured in the USA in a GMP-certified facility, for guaranteed quality and potency.
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Neuro-Immune Stabilizer Topical Cream 1.8 Ounces/ 120 Pumps Read Review

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Product Highlights

  • B12
  • Folinic Acid
  • Pharmaceutical Grade
  • Created by US Physicians
  • Nervous and Immune System Support
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MethylPro 2.5mg L-Methylfolate (30 Capsules) - Professional Strength Active Methyl Folate,... Read Review

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Product Highlights

  • Are You Taking The Wrong Kind Of Folate? Approximately half the US population may have difficulty converting folate into its active form. MethylPro is the leading nutraceutical line featuring l-methylfolate, the most active, advanced form for better results.*
  • Purer, Faster, Stronger - Many methylfolate products contain mcg or 1mg amounts. MethylPro offers a range of therapeutic doses in their fastest, most potent form for a difference you can feel. No fillers or excipients like bulking agents.*
  • Brain & Mood Support - Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, energy, hormones and mood stability. This is the only form of folate to cross the blood-brain-barrier.*
  • Promotes Cardiovascular & Nerve Health - May help promote heart health & healthy peripheral nerve function by supporting already healthy homocysteine levels and nitric oxide production.*
  • No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. The only additional ingredient is the amino acid glycine. This product is free of soy, gluten, dairy, eggs, and nuts. Take only as directed under the supervision of a Physician.*
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MethylPro 10mg L-Methylfolate (30 Capsules) - Professional Strength Active Methyl Folate,... Read Review

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Product Highlights

  • The Leader In Faster, Active Folate - Approximately half the US population may have difficulty converting folate into its active form. MethylPro is the leading nutraceutical line featuring l-methylfolate, the most advanced form for better results.*
  • Professional Strength - Many methylfolate products contain mcg or 1mg amounts. MethylPro offers a wide range of potent therapeutic doses. This product offers a higher dose of 10 mg, for a difference you can feel.*
  • Brain & Mood Support - Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, energy, hormones and mood stability. This is the only form of folate to cross the blood-brain-barrier.*
  • Promotes Cardiovascular & Nerve Health - May help promote heart health & healthy peripheral nerve function by supporting already healthy homocysteine levels and nitric oxide production.*
  • No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. The only additional ingredient is the amino acid glycine. This product is free of soy, gluten, dairy, eggs, and nuts. Take only as directed under the supervision of a Physician.*
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Seeking Health HomocysteX Plus, 60 Capsules, Vitamin B Complex, Active B-Complex Vitamins,... Read Review

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Product Highlights

  • SUPPORT HOMOCYSTEINE PATHWAY: HomocysteX Plus by Seeking Health offers a combination of methylated nutrients that support your homocysteine pathway via the CBS gene so that your homocysteine can help make your body’s number-one antioxidant: glutathione.*
  • IDEAL FOR MTHFR GENE MUTATION: By taking additional TMG, you support methylation not only via MTHFR, but also via the BHMT gene, and all other homocysteine genes are supported because of the targeted active ingredients in HomocysteX Plus.*
  • SUPPORTS HEALTHY BLOOD PRESSURE: High homocysteine dirties the NOS3 gene, which can raise blood pressure. High homocysteine is caused by a lack of the nutrients in HomocysteX Plus. High homocysteine means low nitric oxide. Normal homocysteine means better nitric oxide.*
  • NEUROPATHY SUPPORT: This vitamin B complex supports healthy homocysteine levels, which supports glutathione via homocysteine through the CBS gene, and the added adenosylcobalamin supports nerve health.*
  • CONSISTENT QUALITY: At Seeking Health, every ingredient is carefully sourced, researched, and tested. Each meets strict specifications for manufacturing standards before any ingredient is allowed for use. We use only the highest-quality ingredients.
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Methyl-Elite Methylation Supplements - 5 MTHF, Methylcobalamin 1000mcg Methylated Vitamin... Read Review

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Product Highlights

  • MTHF supplement: Methyl-Elite + offers an all-in-one methylation supplement with folate, methylated vitamins, riboflavin, and betaine in an easy to use capsule format.
  • Folate & riboflavin: 1360 mcg of 5- MTHF folate with Quatrefolic 5 methylfolate and glucosamine salt as a folate supplement. This methylation formula also contains 30 mg of Ribovlavin 5’- Phosphate as a riboflavin supplement.
  • Betaine: The blend features 600 mg of betaine as trimethylglycerine (TMG).
  • Methylated vitamins: Codeage Methyl-Elite + can provide an active, methylated forms of folate and vitamins B2, B6, B12 (5-MTHF and methylcobalamin B12). The vitamins included in this formula (vitamin B6 and vitamin B12 1000 mcg) are also provided in their phosphorylated forms.*
  • Vegan, gluten free, non-GMO, & made in USA: Codeage Methyl-Elite + supplement is vegan, and non-GMO. This formula is also gluten, dairy, and soy free. Codeage methylated vitamins capsules are manufactured in the USA in an cGMP certified facility and third party tested. 2 months supply.
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Pure Encapsulations PureGenomics B-Complex | Broad Spectrum B Vitamin Support for Genetic... Read Review

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Product Highlights

  • Healthy Methylation: PureGenomics B-Complex is designed to address the nutrient requirements of common genetic variations in the methylation pathway with a unique blend of B vitamins in highly researched and activated forms. Healthy methylation is a key regulator of genetic expression and cellular function.*
  • Activated B Vitamins: Provides activated B vitamins, including pyridoxal-5-phosphate, riboflavin-5-phosphate, enhanced-retention thiamin derivative benfotiamine, and 800 mcg of Metafolin L-5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring, universally metabolized form of folate.
  • Vitamin B12 Blend: Vitamin B12, offered as a combination of hydroxocobalamin and adenosylcobalamin, supports proper carbohydrate metabolism and healthy synthesis of neuronal myelin.*
  • Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
  • Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.
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Methyl Multi Without Iron - 240 Vegetable Capsules | This Vegan Formula Features Activated... Read Review

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Product Highlights

  • NEW Look, Same Pure Formula! Methyl Multi "without iron" is an Optimized Formula with Activated Ingredients & Essential Nutrients and is Exceptional for those with defective MTHFR genes. Take 2 capsules (one to two times daily) for best results.
  • VITAMIN K2 as MK-7 (MenaQ7 Crystals- from chickpeas) and BORON (as Albion Bororganic Glycine). *IMPROVED: MecobalActive "The active form of B12" ; Thaimine as Benfotiamine (Benfopure), Selenium (as Albion selenium glycinate complex); Zinc (as TRAACS zinc bisglycinate chelate); Potassium (as Albion potassium glycinate complex). NO Fillers, excipients, flow agents, nothing but active ingredients.
  • FOUNDATIONAL "Dietary Insurance" to Support a Healthy Lifestyle. Multi-nutrient Supplement Providing Exceptional Broad-Spectrum Nutritional Support
  • SUPPORTS Antioxidant Protection & Supports Detoxification*
  • PHARMACEUTICAL GRADE - Manufactured in the USA in an NSF and GMP-certified facility, for guaranteed quality and potency.
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Vital Nutrients - Vitamin B12 / Methyl Folate - Supports Healthy Brain Cell Function - 100... Read Review

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Product Highlights

  • Supports Gastrointestinal Tract Health: This methylated form of Vitamins B12 (methylcobalamin) and Folate (Metafolin L-5-MTHF) work together to support the metabolism of protein and fats, which helps maintain a healthy gastrointestinal tract.*
  • Supports Nervous System: Vitamin B-12 supports a healthy myelin sheath, healthy nerves, energy production and proper brain function in healthy adults.*
  • Maintains Homocysteine Levels: Homocysteine is a natural amino acid made by the body during the metabolism of methionine. Healthy homocysteine levels support immune function and brain and cardiovascular health.*
  • Does Not Contain: This product is free from coatings, binders, gluten (wheat, rye, barley)*, milk/dairy (casein, whey)*, soy protein*, egg protein*, and sugar*. *Verified by independent testing.
  • We test every ingredient we use and every finished product we make. FDA regulation (GMP Part 111) requires that manufacturers test ingredients and finished products. However, it allows manufacturers to perform minimal “skip lot testing” meaning only some of the ingredients are tested. Vital Nutrients has always exceeded these testing requirements by performing a significant number of additional tests on raw ingredients and finished products at independently certified U.S. labs. Labels may vary.
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MethylPro 15mg L-Methylfolate (60 Capsules) - Professional Strength Active Methyl Folate,... Read Review

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Product Highlights

  • The Leader In Faster, Active Folate - Approximately half the US population may have difficulty converting folate into its active form. MethylPro is the leading nutraceutical line featuring l-methylfolate, the most advanced form for better results.*
  • Professional Strength - Many methylfolate products contain mcg or 1mg amounts. MethylPro offers a range of potent therapeutic doses. This 15 mg dose is our strongest, for a difference you can feel.*
  • Brain & Mood Support - Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, energy, hormones and mood stability. This is the only form of folate to cross the blood-brain-barrier.*
  • Promotes Cardiovascular & Nerve Health - May help promote heart health & healthy peripheral nerve function by supporting already healthy homocysteine levels and nitric oxide production.*
  • No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. The only additional ingredient is the amino acid glycine. This product is free of soy, gluten, dairy, eggs, and nuts. Take only as directed under the supervision of a Physician.*
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Actif Methylation Mega Support with 10 Advanced Factors, 5-MTHF (Organic Folate) - 100% Na... Read Review

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Product Highlights

  • ★ COMPLETE METHYLATION SUPPORT: Full B Vitamin Complex (B1, B6, B12), Folate, and Essential Methylation Factors (TMG, Zinc, Magnesium) in potent dosage to support the entire process.
  • ★ PROMOTES HEALTHY HOMOCYSTEINE PATHWAY: Allowing for normal production of its end products.
  • ★ ORGANIC SOURCED FOLATE 5-MTHF: Provides the most bioavailable form of folate for easy absorption.
  • ★ BOOSTS IMMUNE System, Memory, Energy, and Cardiovascular Health.
  • ★ Non-GMO, gluten-free, allergen-free, pharmaceutical grade ingredients.
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L Methylfolate 15mg | 120 Capsules | Value Size | Max Potency | Optimized and Activated |... Read Review

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Product Highlights

  • Gluten Free, Non-GMO; Free Of Wheat, Yeast, Milk, Lactose, Soy, Artificial Color, Artificial Flavor
  • Each L-Methylfolate (5-MTHF) capsule provides you with 15 mg of this bioavailable form of folic acid
  • Folate, also referred to as Folic Acid, is a fully active B complex vitamin
  • Our professional formula is backed by our commitment to purity and potency
  • Manufactured in a facility that is GMP certified
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Standard Process Gastrex - Whole Food Digestion and Digestive Health with Oat Straw, Choli... Read Review

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Product Highlights

  • Supports GI cleansing through the elimination of waste materials
  • Suggested use: Take two capsules with a full glass of water 15 minutes before meals and bedtime, or as directed
  • Standard Process: High-quality products that work the way nature intended
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Metabolic Maintenance L-Methylfolate 5mg - Active Folate (L-5-MTHF) + Glycine Supplement -... Read Review

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Product Highlights

  • Get The Right Kind Of Folate - About half of the US population have a reduced ability to convert folic acid to 5-MTHF, the activated form of folate.*
  • Active & Bioavailable - Our L-Methylfolate is a more active, bioavailable form of folate. It is the only form of folate to cross the blood-brain-barrier.*
  • Cardiovascular, Nerve, & Mood Support - 5-MTHF is important for normal production of the neurotransmitters serotonin, norepinephrine, and dopamine. It also plays a part in the maintenance of cardiovascular and nerve health.*
  • Purity, Quality, Potency - No fillers, binders, preservatives, artificial colors or flavors. Vegetarian capsules. No gluten, egg, peanuts, tree nuts, or magnesium stearate. Supplements arrive in BPA-Free, recycled amber bottles that protect from light contamination.
  • Physician's Choice - The health care professional's choice for high-quality supplements since 1984. We base our products on the latest wellness research and clinical studies, and use third-party testing for all incoming, in-process, and finished product. Products you can trust, at an exceptional value.
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NatureGenx - Methylation Protect Chewable - Active B12 with L-5-MTHF - MTHFR Support Suppl... Read Review

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Product Highlights

  • ✅Chewable Methulfolate ( Optimized Folate and Vitamin B12) includes the Active Chewable B12 with L-Methylfolate 1000 mcg . It does not have to be converted, so it starts working right away, making Methylcobalamin the most stable and bioavailable form of vitamin B12. Methylation is important to good health and well-being. Our active vitamin B12 tablets make this process easy for your body for mthfr support supplement.
  • ✅ Active form of Chewable B12★ Methylcobamin is the active form of methylfolate B12. It does not have to be converted so it starts working right way. Many suffer from folate deficiency because folates normally found in foods are unstable, and rapidly lose activity during food processing, manufacturing, and storage. Common folic acid supplements are converted to the active form before they are absorbed and utilized by the body. Our tablets are ready for your body to use.
  • ✅Supports Brain Function★ the methylation process is important for a variety of bodily functions, and our B12 vitamin tablets help your body with this process. One primary benefit is improved brain activity. Other benefits include mood balancing, energy production, immune function, detoxification, and production of enzymes, hormones, neurotransmitters, antibodies, vitamins, and cell membranes.
  • ✅Effective Prenatal Vitamin★ In addition to the many general bodily functions that our B12 vitamin tablets support, our active B12 supplement is also recommended for a prenatal vitamin for general use during childbearing years and pregnancy. However, if you are pregnant or nursing you should consult your healthcare practitioner before taking this product.
  • ✅MTHFR ❤ the MTHFR gene is responsible for how much methylfolate is produced in the body. Our body needs methyl folate for a proper metabolism. If there is not enough methyloate in the body, it leads many serious health problems. Our Methylation Protect Chewable Active B12 is Quatrefolic from Gnosis,the new generation of folic acid. Quatrefolic uses a vegetarian-sourced glucosamine salt and has been proven in studies to have greater bioavailability over calcium salt versions.
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Allergy Research Group - QuatreActiv Folate - 5-MTHF, Methylation Support - 90 Vegetarian... Read Review

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Product Highlights

  • Provides Quatrefolic, the glucosamine salt of 5-methyltetrahydrofolate (5-MTHF).
  • Unlike folic acid, QuatreActive Folate can be used by the body without further conversion*
  • Suggested Use: Take 1 capsule one or two times daily, or as directed by a healthcare practitioner
  • Free of wheat and gluten, dairy, eggs, soy, fish, shellfish, peanuts, tree nuts, corn, and yeast
  • Since 1979 Allergy Research Group has committed to using pure and low allergy potential ingredients
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Double Strength & Most Bioactive Methyl Folate! Uniquely Formulated with Highest Pharmaceu... Read Review

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Product Highlights

  • ♥ Lab tested and most powerful Methylfolate supplying essential support for DNA and neurotransmitter synthesis along with amino acid metabolism.
  • ♥ Developed as most optimally absorbed and bioavailable 5-MTHF
  • ♥ Delivering key supplementation for brain, heart and nerve function, as well as support for women who are pregnant and overall health
  • ♥ Suitable for people who are diagnosed with MTHFR mutation
  • ♥ To ensure purity and safety, our products are manufactured in a fully GMP-certified facility. Our product is third party tested to assure the quality and purity of each batch. All Made in USA.
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Metabolic Maintenance L-Methylfolate 10mg - High Dose Active Folate (L-5-MTHF) + Glycine S... Read Review

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Product Highlights

  • Take The Right Kind Of Folate - About half the US population have a reduced ability to convert folic acid to 5-MTHF, the activated form of folate.*
  • Active & Bioavailable - Our L-Methylfolate is a more active, bioavailable form of folate. It is the only form of folate to cross the blood-brain-barrier.*
  • Cardiovascular, Nerve, & Mood Support - 5-MTHF is important for production of the neurotransmitters serotonin, norepinephrine, and dopamine. It also plays a part in the maintenance of cardiovascular and nerve health.*
  • Purity, Quality, Potency - No fillers, binders, preservatives, artificial colors or flavors. Vegetarian capsules. No gluten, egg, peanuts, tree nuts, or magnesium stearate. Supplements arrive in BPA-Free, recycled amber bottles that protect from light contamination.
  • Physician's Choice - The health care professional's choice for high-quality supplements since 1984. We base our products on the latest wellness research and clinical studies, and use third-party testing for all incoming, in-process, and finished product. Products you can trust, at an exceptional value.
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Klaire Labs Methyl Balance - Metabolism & Methylation Support with Active Folate, B2, B12,... Read Review

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Product Highlights

  • A unique formula that combines bioactive forms of four essential B vitamins with trimethylglycine (betaine).*
  • Vitamins B2, B6, B12, and folate are provided in active, coenzyme forms for maximal bioavailability and function.*
  • These ingredients work together to synergistically support methylation processes and help maintain normal homocysteine metabolism.*
  • Hypoallergenic* product free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and corn. Contains no artificial colors, flavors, or preservatives.
  • Trusted by healthcare practitioners since 1969, Klaire Labs products are developed closely with physicians and are intended to be used as directed by a healthcare practitioner.
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Methyl B Complete - 120 Vegetable Capsules | Optimal Methylation Support Supplement with Q... Read Review

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Product Highlights

  • NEW Look, Same Powerful Formula! Methyl B Complete is exceptional for those with defective MTHFR genes. A comprehensive b complex designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range. Provides bioactive forms of four essential B-vitamins together with Trimethylglycine (TMG) to synergistically support methylation processes and normal homocysteine metabolism. Made in the USA in a GMP-certified facility, for guaranteed quality & potency.
  • 4 MONTH SUPPLY (120 capsules) - Methyl B Complete is the most advanced MTHFR formula on the market at an affordable price. Each capsule contains 2000 mcg of the patented Quatrefolic which is the most biologically active form of active folate "5-MTHF".
  • FEATURES five key nutrients that are involved in homocysteine metabolism: folate as Quatrefolic for increased bioactivity; Betaine (also known as trimethylglycine or TMG); and vitamins B12 (Methylcobalamin & Adenosylcobalamin), B6, and B2. These five nutrients, provided in activated forms, support enhanced methylation and overall cardiovascular health.
  • WHAT'S NOT THERE IS ALMOST AS IMPORTANT AS WHAT IS: We formulated our product with your needs in mind, that's why it is non-GMO, soy and gluten free, and unlike other brands does not contain the additive magnesium stearate which is thought to potentially inhibit absorption of key nutrients.
  • SUPPORTS the Maintenance of Healthy Homocysteine Levels Already Within Normal Range, Healthy Methylation of Estrogen, Dopamine, Epinephrine, Heavy Metals, Environmental Toxins, Cardiovascular and Neurological Health
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Pure Encapsulations MethylAssist | Supplement with B Vitamins to Support Cardiovascular, N... Read Review

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Product Highlights

  • Methylation Support: Supports essential methylation reactions to support cardiovascular and neural health with Metafolin L-5-methyltetrahydrofolate (L-5-MTHF), the naturally occurring, universally metabolized form of folate, and activated B vitamins.*
  • Psychological Health: Optimal levels of B vitamins have been associated with neurological and psychological health.*
  • Nerve Health: Maintains healthy nervous system function and comfort including healthy nerve conduction velocity.*
  • Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
  • Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.
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Thorne Research - Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B1... Read Review

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Product Highlights

  • Methylation: Support for healthy methylation*
  • Multiple Functions: Support for heart, blood vessel, brain, nerve, and bone health*
  • Homocysteine: Promotes homocysteine metabolism*
  • Active Bs: Contains the active, methylated forms of folate and vitamin B12 (5-MTHF and methylcobalamin)
  • Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts). This product also contains no soy, dairy, yeast, shellfish, or fish.
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Designs for Health Lithium Synergy - 5mg Lithium Orotate with TMG + B12 Methylcobalamin -... Read Review

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Product Highlights

  • MAY SUPPORT MOOD AND MEMORY - Research shows that lithium supports the health and function of the hippocampus, a part of the brain that supports mood and memory in already healthy individuals.*
  • OPTIMAL BIOAVAILABILITY - Lithium orotate is lithium bound to orotic acid, which improves its bioavailability.*
  • HELPS SYNTHESIZE SAMe - The addition of vitamin B12 and trimethylglycine (TMG) to Lithium Synergy helps support healthy methylation pathways. Vitamin B12 is also needed for the synthesis of SAMe.*
  • ALWAYS PURE & EFFECTIVE PRODUCTS - This product is Vegetarian-Friendly, Non-GMO, and contains No Gluten, Dairy, or Soy. DFH is transitioning to tinted glass bottles. In addition to being more eco-conscious, tinted glass offers a greater moisture barrier against moisture and oxygen, which helps protect nutrient viability.*
  • OVER 50,000 DOCTORS AGREE - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.
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Neurobiologix Methylation Complete™ 120 Sublingual Tablets with Bioactive B12, Methyl Fola... Read Review

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Product Highlights

  • Mood Improvement & Stabilization*
  • Short Term Memory*
  • MTHFR / MTRR Mutations*
  • Sleep Patterns*
  • Immune Health*
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Seeking Health L-5-MTHF Capsules, Supports Healthy Methylation, Easily Absorbed Methyl Fol... Read Review

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Product Highlights

  • L-5 MTHF Health Supplements – Pure, methylated folate is easily absorbed by the body and can provide vital nutrients to those with absorption or metabolic disorders or MTHFR gene mutations*. Each bottle contains 60 capsules of 1,700 mcg DFE L-5 MTHF.
  • Prenatal Regimen – Methylated folate helps DNA and RNA synthesis to create new cells and may support a healthy nervous system. Along with a healthy diet and exercise, L methyl folate may support pregnant women and fetal development.*
  • Easily Absorbed – Folate is a naturally occurring B vitamin found in leafy greens, beans, and citrus. Seeking Health L-5-MTHF is a gentle, bioavailable form of folate that is optimized for easy absorption and is suitable for vegans and vegetarians.*
  • Quality Health Supplements – Seeking Health Supplements are manufactured according to strict standards to ensure product purity and quality. L-5 MTHF is GMO-free and allergen-friendly.
  • Support Genetic Health – Seeking Health provides quality, scientifically-formulated health supplements to optimize health. In a world packed with toxins and stress, we believe that gene health starts with pure, bioavailable, easy-to-use supplements.
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Quicksilver Scientific Methyl Charge+ - Methylation, Liver, Detox + Energy Support - Folat... Read Review

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Product Highlights

  • Methylation Support - A thoughtful blend of four key B vitamins (methyl B12, folate, B6 and Riboflavin) and TMG designed to keep the wheels of the methylation cycle turning.*
  • Support NAD+ Production - NAD+ and methylation cycles are closely interconnected. Pairing Methyl Charge with your NAD+ supplements supports optimal synergy.*
  • Promote Detox & Energy Production - The methylation cycle affects glutathione production, detoxification, and processes related to aging and energy production.*
  • Fast-Acting Absorption Technology - Delivered to the body with state-of-the-art liposomal delivery. Designed to offer complete uptake through the cells of the mouth and directly into the bloodstream for results you can feel.*
  • Non-GMO & Tested Gluten Free - This product is vegan, Non-GMO and tested gluten free. The phospholipids are from purified sunflower lecithin.
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MethylPro 7.5mg L-Methylfolate (90 Capsules) - Professional Strength Active Methyl Folate,... Read Review

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Product Highlights

  • Are You Taking The Wrong Kind Of Folate? Approximately half the US population may have difficulty converting folate into its active form. MethylPro is the leading nutraceutical line featuring l-methylfolate, the most active, advanced form for better results.*
  • Purer, Faster, Stronger - Many methylfolate products contain mcg or 1mg amounts. MethylPro offers a range of therapeutic doses in their fastest, most potent form for a difference you can feel. No fillers or excipients like bulking agents.*
  • Brain & Mood Support - Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, energy, hormones and mood stability. This is the only form of folate to cross the blood-brain-barrier.*
  • Promotes Cardiovascular & Nerve Health - May help promote heart health & healthy peripheral nerve function by supporting already healthy homocysteine levels and nitric oxide production.*
  • No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. The only additional ingredient is the amino acid glycine. This product is free of soy, gluten, dairy, eggs, and nuts. Take only as directed under the supervision of a Physician.*
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L Methyl Folate 15mg Plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form... Read Review

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Product Highlights

  • PROFESSIONAL STRENGTH: Provides clinically validated dosage of 15mg L Methyl folate in the 5-MTHF calcium salt form. This is the most active form of Folate.
  • ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is crucial for those with methylation issues that cannot properly process folic acid.
  • BRAIN, MOOD & ENERGY SUPPORT: Essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.*
  • CARDIOVASCULAR, NITRIC OXIDE & NERVE SUPPORT: Supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.
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Thorne Research - Methyl-Guard Plus - Methylation Support Supplement with 5-MTHF (Folate)... Read Review

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Product Highlights

  • Healthy Methylation: Methyl-Guard Plus supports methylation and promotes a healthy level of homocysteine
  • Active Forms: Formulated with active folate (5-MTHF) and the active, tissue-ready forms of vitamins B2, B6, and B12 to optimize absorption
  • Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health
  • Free From: Doesn't contain gluten, eggs, tree nuts, peanuts, dairy, yeast, soy, fish, or shellfish
  • Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams
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Garden of Life RM-10 Ultra Ultimate Broad Spectrum Immune Support System for Cell Function... Read Review

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Product Highlights

  • FERMENTED MUSHROOMS: RM-10 Ultra is a combination of 10 organically grown, tonic mushrooms and other specially selected nutrients for immune system support
  • SELENIUM: This mushroom supplement is balanced with L-theanine, selenium, lycopene and other ingredients that promote healthy immune system function
  • MULTIPLE BENEFITS: RM-10 Ultra provides broad spectrum immune support via multiple pathways: immune cell function support, immune cell metabolism support, methylation support and antioxidant support
  • VEGETARIAN: This immune booster is delivered by UltraZorbe 100% vegetarian capsule with no fillers or binders for quick nutrient release
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
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Power By Naturals Active Chewable B12 with L-Methylfolate (5 MTHF) Dr Formulated – Vitamin... Read Review

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Product Highlights

  • ✅ Doctor Formulated Methyl B12 - Active Chewable B12 Vitamins - Our Chewable Vitamin B12 with L-methylfolate includes the active form of B12, Methylcobalamin. It does not have to be converted, so it starts working right away, making Methylcobalamin the most stable and bioavailable form of vitamin B12. Methylation is important to good health and well-being. Our active vitamin B12 tablets make this process easy for your body.
  • ✅ Quatrefolic Folate and Folic Acid Supplement ( 5-mthf plus Multi B Vitamin) - Many suffer from folate deficiency because folates normally found in foods are unstable, susceptible to oxidation, and rapidly lose activity during food processing, manufacturing, and storage. Common folic acid supplements are converted to the active form before they are absorbed and utilized by the body. Our tablets are ready for your body to use.
  • ✅ Methylated B12 Support Brain Function - The methylation process is important for a variety of bodily functions, and our Vit B Comlex tablets help your body with this process. One primary benefit is improved brain activity. Other benefits include mood balancing, energy production, immune function, detoxification, and production of enzymes, hormones, neurotransmitters, antibodies, vitamins, and cell membranes
  • ✅ Vitamin B12 Supplements - Vegetarian and Gluten Free Ingredients (Bitamin B complex) - Quatrefolic from Gnosis is a new generation of folic acid. Quatrefolic uses a vegetarian-sourced glucosamine salt and has been proven in studies to have greater bioavailability over calcium salt versions. Our ingredients are also gluten free. You can trust that Power By Naturals’ Active Chewable Vitamin B12 is made with high-quality ingredients.
  • ✅ Vitamina B12 - Effective Prenatal Vitamin (Pure B Complex)- In addition to the many general bodily functions that our B12 vitamin tablets support, our active B12 supplement is also recommended for a prenatal vitamin for general use during childbearing years and pregnancy. However, if you are pregnant or nursing you should consult your healthcare practitioner before taking this product.
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MethylPro 15mg L-Methylfolate (30 Capsules) - Professional Strength Active Methyl Folate,... Read Review

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Product Highlights

  • The Leader In Faster, Active Folate - Approximately half the US population may have difficulty converting folate into its active form. MethylPro is the leading nutraceutical line featuring l-methylfolate, the most advanced form for better results.*
  • Professional Strength - Many methylfolate products contain mcg or 1mg amounts. MethylPro offers a range of potent therapeutic doses. This 15 mg dose is our strongest, for a difference you can feel.*
  • Brain & Mood Support - Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, energy, hormones and mood stability. This is the only form of folate to cross the blood-brain-barrier.*
  • Promotes Cardiovascular & Nerve Health - May help promote heart health & healthy peripheral nerve function by supporting already healthy homocysteine levels and nitric oxide production.*
  • No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. The only additional ingredient is the amino acid glycine. This product is free of soy, gluten, dairy, eggs, and nuts. Take only as directed under the supervision of a Physician.*
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Omnivits Methyl Defense Optimal Methylation Support Formula | Methylation Protect for You... Read Review

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Product Highlights

  • Methyl Defense is a comprehensive formula designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range.
  • It features five key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic for increased bioactivity; trimethylglycine; and vitamins B12, B6, and B2. These five nutrients, provided in activated forms, support enhanced methylation and overall cardiovascular health.*
  • Supports Cardiovascular and Neurological Health*
  • Supports the Maintenance of Healthy Homocysteine Levels Already Within Normal Range*
  • Supports Healthy Methylation of Estrogen, Dopamine, Epinephrine, Heavy Metals, and Environmental Toxins*
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Methyl B Synergy | Complete Methylation Support* | 120 V-Caps | Patented Quatrefolic ® as... Read Review

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Product Highlights

  • Supports Healthy Methylation of Estrogen, Dopamine, Epinephrine, Heavy Metals, and Environmental Toxins*
  • Supports the Maintenance of Healthy Homocysteine Levels Already Within Normal Range*
  • Active Folate as Quatrefolic 5-MTHF, B-12 as Methylcobalamine, Betaine for Bio-availability
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Metabolic Maintenance L-Methylfolate 15mg - High Dose Active Folate (L-5-MTHF) + Glycine S... Read Review

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Product Highlights

  • Get The Right Kind Of Folate - About half of the population have genetic variations that reduce the ability to convert folic acid to 5-MTHF, the activated form of folate used by the body for many biochemical reactions.*
  • Active & Bioavailable - Our L-Methylfolate is a more active, bioavailable form of folate. It is the only form of folate to cross the blood-brain-barrier.*
  • Cardiovascular, Nerve, & Mood Support - 5-MTHF is important for normal production of the neurotransmitters serotonin, norepinephrine, and dopamine. It also plays a part in the maintenance of cardiovascular and nerve health.*
  • Purity, Quality, Potency - No fillers, binders, preservatives, artificial colors or flavors. Vegetarian capsules. No gluten, egg, peanuts, tree nuts, or magnesium stearate. Supplements arrive in BPA-Free, recycled amber bottles that protect from light contamination.
  • Physician's Choice - The health care professional's choice for high-quality supplements since 1984. We base our products on the latest wellness research and clinical studies, and use third-party testing for all incoming, in-process, and finished product. Products you can trust, at an exceptional value.
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Seeking Health | Optimal Methylate Chewable | B-Complex with Active Form of Folate | Methy... Read Review

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Product Highlights

  • CONTAINS ACTIVE FORMS OF FOLATE, VITAMIN B12 AND NINE OTHER TARGETED NUTRIENTS
  • HELPS SUPPORT AND OPTIMIZE HEALTHY METHYLATION PROCESSES throughout the body
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Designs for Health Homocysteine Supreme - Methylation + Cardiovascular Support Supplement... Read Review

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Product Highlights

  • Homocysteine Metabolism Support - Contains synergistic nutrients known to facilitate the efficient metabolism of homocysteine. Features B vitamins in their methylated forms and TMG.* NOTE: This product has been reformulated, please refer to supplement facts for details.
  • Superior Form Of Folate - Includes Quatrefolic, a patented active form of folate (L-5-MTHF) known to help facilitate the efficient metabolism of homocysteine.*
  • Cardiovascular Support - A healthy homocysteine pathway is needed for cardiovascular health, brain health, healthy aging, the immune system, healthy detoxification, and joint support.*
  • Vegetarian & Non-GMO - This product is Vegetarian-Friendly. Made without GMOs, Gluten, Soy or Dairy. Tinted glass bottles offer a barrier against moisture and oxygen, which helps protect nutrient viability.*
  • Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.
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Premium Methylation Support for Healthy Heart and Brain. Methylfolate (B9) Uniquely Formul... Read Review

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Product Highlights

  • MADE WITH PATENTED Quatrefolic, 5-MTHF, developed as the most bioavailable methylfolate on the market.
  • UNIQUELY FORMULATED to include 5 key nutrients in their most bioactive forms to help optimize methylation and homocysteine levels for a healthy heart and brain.
  • SUPERIOR SUPPORT for people diagnosed with MTHFR gene mutation.
  • HELPS MAINTAIN healthy homocysteine levels for vascular health, heart health, eye health, and optimal brain function.
  • PURE BY DESIGN - ALWAYS. At BioFlourish, we make products for ourselves and our families so we select only the best premium quality, all-natural, science-based ingredients manufactured to the highest GMP standards at a beautiful, earth-friendly facility in Oregon, USA. All ingredients hypoallergenic, Vegan, and Non-GMO.

"Amazon, Amazon Prime, the Amazon logo and Amazon Prime logo are trademarks of Amazon.com, Inc. or its affiliates". AS AN AMAZON ASSOCIATE, WE EARN AFFILIATE COMMISSIONS FROM QUALIFYING PURCHASES.

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